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目的:探讨血清肿瘤标志物对于消化系统肿瘤的诊断价值,评价其临床意义。方法:对于2010年6月-2011年12月在我院治疗的85例消化系统恶性肿瘤患者,同时以同期在本院进行健康体检的60例健康人作为对照,对两组患者的CEA、CA199、CA125及AFP含量进行检测,主要采用放射免疫分析技术对其含量进行检测。结果:消化系统肿瘤组患者血清中的CEA、AFP、CA125及CA199水平均高于对照组患者,两组间差异具有统计学意义(P<0.05);对于胃癌患者,其CEA的阳性率最高,达到67.4%,而AFP阳性率最低,各个指标之间差异具有统计学意义(P<0.05);对于肝癌患者,其AFP阳性率最高,达到82.3%,而CEA阳性率最低,各个指标之间差异具有统计学意义(P<0.05);对于胰腺癌患者而言,其AFP的阳性率最高,达到52.6%,而CEA阳性率最低,各个指标之间差异具有统计学意义(P<0.05);对于直肠癌患者而言,其CA199的阳性率最高,达到83.6%,而AFP阳性率最低,各个指标之间差异具有统计学意义(P<0.05)。结论:多种肿瘤标志物联合检测对于消化系统恶性肿瘤患者具有很好的诊断价值,能够提高消化系统恶性肿瘤患者诊断的阳性率,在术前诊断中具有很好的临床应用价值。
Objective: To investigate the diagnostic value of serum tumor markers for digestive system tumors and evaluate its clinical significance. Methods: A total of 85 patients with digestive system malignancies treated in our hospital from June 2010 to December 2011 were enrolled in this study. Sixty healthy subjects who underwent physical examination in our hospital during the same period were enrolled in this study. CEA, CA199 , CA125 and AFP content were detected, mainly using radioimmunoassay to detect its content. Results: The serum levels of CEA, AFP, CA125 and CA199 in patients with digestive system tumors were significantly higher than those in control patients (P <0.05). The positive rates of CEA in patients with gastric cancer were the highest, (P <0.05). The positive rate of AFP in patients with hepatocellular carcinoma was the highest (82.3%), while the positive rate of CEA was the lowest (P <0.05). The positive rate of AFP was the lowest (P <0.05). The positive rate of AFP was the highest in patients with pancreatic cancer (52.6%), while the positive rate of CEA was the lowest (P <0.05). For the patients with pancreatic cancer, the positive rate of AFP was the highest The positive rate of CA199 in patients with rectal cancer was the highest (83.6%), and the lowest was AFP. There was a significant difference between each index (P <0.05). Conclusion: The combined detection of multiple tumor markers has a good diagnostic value for patients with digestive system malignancies, which can improve the positive rate of diagnosis in patients with digestive system malignancies and has a good clinical value in preoperative diagnosis.