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本文报告山东省六个综合性医院和十三个疗养院,1964年5月～66年4月两年间胃肠道给氧治疗肝炎,肝硬化406例(内有皮7·16例)的临床总结。通过严格对比明确了氧气治疗肝炎的效果较“保肝药物”为优。急肝、迁肝,慢肝单用氧的有效率分别为84.6%,68.1%,50%,对肝硬化的疗效不明显。氧疗对迁肝食欲减退及腹胀的有效率各为85%及80%以上,大部分病人于一月内奏效。迁肝氧疗肝缩率为65±%,脾缩率为30±%,对谷丙转氨酶有效率为68.8%,蛋白质合成障碍的恢复人数在一半以上。慢肝恢复的情况较上述迁肝者略差;对五组“保肝药物”疗效不佳的病例,加用氧或换用氧后出现了较好的效果。病理组织上的观察亦说明了氧疗肝炎的效果。氧气治疗肝炎无何痛苦,费用小,方法简便,符合多,快、好、省的精神。通过实验观察证明:(1)胃肠道给氧可使门脉血氧升高,(2)人胃给氧可增强胃节律性运动,促使胃液(酸度及胃蛋白酶)分泌,并增强胰液分泌。(3)大白鼠实验对Ccl_4所致肝损害,胃肠道给氧可使肝组织的氧化辛酸能力降低较对照组为轻。同样病理上看到给氧组发生脂肪肝较轻,早期肝硬化者较少。初步地解释了氧疗肝炎的临床变化。对无效病例做了原因探讨,认为长期活动性慢性肝炎和迁肝恢复期,氧疗效果较差。
This article reports the clinical summary of 406 gastrointestinal tract hemorrhagic hepatitis patients and cirrhosis (7.16 cases) in the two general hospitals and 13 nursing homes in Shandong province between May 1964 and April 66 . Through rigorous contrast clear that the effect of oxygen treatment of hepatitis than the “liver medicine” is excellent. The acute liver, liver, slow liver single oxygen efficiency were 84.6%, 68.1%, 50%, the effect of cirrhosis is not obvious. Oxygen therapy on liver dysfunction and bloating reduce the efficiency of 85% and 80%, respectively, most of the patients worked within January. Hepatic oxygen therapy liver shrinkage of 65 ±%, the rate of 30 ±% of spleen, alanine aminotransferase efficiency of 68.8%, protein synthesis disorders in more than half the number of recovery. The recovery of chronic liver is slightly worse than that of the above-mentioned liver transplantors. The five groups of “hepatoprotective drugs” did not work well with oxygen or oxygen exchange. The observation of pathology also shows the effect of oxygen therapy on hepatitis. Oxygen treatment of hepatitis without any pain, the cost is small, the method is simple, in line with more, faster, better, provincial spirit. The experimental observations show that: (1) gastrointestinal oxygen can portal blood oxygen increased, (2) human gastric oxygen can increase gastric rhythmic exercise, to promote gastric juice (acidity and pepsin) secretion, and enhance pancreatic secretion . (3) The experimental rat liver damage caused by Ccl_4, gastrointestinal oxygen can reduce the ability of ocular acid oxidation of liver tissue lighter than the control group. The same pathology to see the occurrence of fatty liver oxygen group lighter, less early cirrhosis. The initial interpretation of the clinical changes of oxygen therapy hepatitis. The reasons for invalid cases were discussed, that long-term active chronic hepatitis and liver recovery, oxygen therapy less effective.