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淋巴管生长因子C（ VEGF-C）有促进血管和淋巴管新生的作用。以往研究表明，肿瘤患者的VEGF-C过表达与肿瘤转移有相关性。近年研究表明，VEGF-C和血管疾病密切相关。在高血压、动脉粥样硬化、心肌梗死、心力衰竭等血管疾病中，VEGF-C及其受体表达明显提高，对VEGF-C／血管内皮生长因子受体-3信号通路的研究有望成为血管病治疗的新手段。现对VEGF-C及其受体的结构和功能，以及VEGF-C和血管疾病发生发展的可能机制进行综述。“,”VEGF-C( vascular endothelial growth factor-C) is a specific regulatory factor of endothelial cell of lymphatic vessels ,which can promote the angiogenesis and lymphangiogenesis .Previous studies had indicated that there was a correlation between VEGF-C over-ex-pression and tumor metastasis in cancer patients .Recent studies show that VEGF-C and vascular diseases are closely related .The expression of VEGF-C and its receptors were significantly increased in vascular diseases , such as hypertension , atherosclerosis , myocardial infarction , heart failure and more.Therefore,the study on the signaling pathway of VEGF-C/VEGFR-3 is expected to be a new method for the treatment of vascular diseases .This article reviews the structure and function of the VEGF-C and its receptor ,and the possible mechanism of the VEGF-C and vascular diseases .