论文部分内容阅读
目的探讨糖尿病孕妇对其新生儿脐血脑损伤神经标志物S100B、MBP、NSE的影响。方法选取2014年1月至2016年12月在濮阳市妇幼保健院产科收治分娩的孕妇232例及其新生儿的病例资料。入选产妇分为5组:将在本院进行孕前检查、并做孕后定期体检血糖正常的孕妇60例作为对照组。将孕前确诊为糖尿病患者81例分为DM-1组(48例,实施降糖干预治疗)、DM-2组(33例,未实施降糖干预治疗)。将孕后确诊的糖尿病患者91例,也分为两组,GDM-1组52例(实施降糖干预治疗),GDM-2组39例(未实施降糖干预治疗)。除对照组外,其他组总称研究组。每组新生儿在出生时用一次性无菌针管抽取3mL-4mL脐静脉血,分别进行NSE、S100B、MBP检测,并进行对比分析。结果研究组与对照组比较,脐血NSE、S100B水平均明显升高,P<0.05;DM-1组、GDM-1组分别与DM-2组、GDM-2组比较,DM-1组、GDM-1组NSE、S100B水平明显降低,P<0.05;GDM-2组NSE、S100B水平比DM-2组升高更明显,P<0.05;GDM-2组脐血MBP水平分别和其他各组比较,P<0.05。结论糖尿病患者新生儿脐血中NSE、S100B、MBP水平会明显升高,糖尿病患者实施干预治疗对改善NSE、S100B、MBP水平、降低新生儿脑损伤有重要意义。
Objective To investigate the effects of diabetic pregnant women on their neonatal cord blood brain injury neurological markers S100B, MBP, NSE. Methods From January 2014 to December 2016, 232 pregnant women and their newborns in obstetrics and gynecology admitted to Puyang Maternal and Child Health Hospital were enrolled. Selected mothers were divided into 5 groups: will be in our hospital for pre-pregnancy examination, and do regular physical examination after pregnancy, normal pregnant women, 60 cases of pregnant women as a control group. 81 cases diagnosed with diabetes before pregnancy were divided into DM-1 group (48 cases, the implementation of hypoglycemic intervention), DM-2 group (33 cases, not implemented hypoglycemic intervention). Ninety-one diabetic patients diagnosed during pregnancy were also divided into two groups: GDM-1 group (n = 52) and hypoglycemic intervention group (n = 39). In addition to the control group, the other groups collectively referred to the study group. Each group of newborns at birth with a disposable sterile needle extraction 3mL-4mL umbilical cord blood, respectively, NSE, S100B, MBP detection, and comparative analysis. Results Compared with control group, the levels of NSE and S100B in umbilical cord blood of study group were significantly increased (P <0.05). Compared with DM-2 group and GDM-2 group, DM-1 group and GDM- The levels of NSE and S100B in GDM-1 group were significantly lower than those in DM-2 group (P <0.05). The levels of NSE and S100B in GDM-2 group were significantly higher than those in DM-2 group Comparison, P <0.05. Conclusion The levels of NSE, S100B and MBP in cord blood of neonates with diabetes mellitus are significantly increased. Intervention therapy in patients with diabetes mellitus plays an important role in improving the levels of NSE, S100B and MBP, and decreasing neonatal brain injury.