为了从天然资源中寻找新的有效治疗阿尔茨海默病的乙酰胆碱酯酶抑制剂,采用Ellman分光光度法对生长于土耳其的多种石松属植物进行了体外筛选,其中仅伸筋草(Lycopodiumclavatum)提取物具有活性。干燥的石松属植物地上部分粉碎后以氯仿-甲醇(1∶1)室温提取3次,40℃真空干燥除去溶 In order to find new acetylcholinesterase inhibitors effective in the treatment of Alzheimer’s disease from natural resources, Elinman spectrophotometry was used to screen various species of Lycopodium grown in Turkey, including only Lycopodium clavatum. The extract is active. The aerial parts of the dried Lycopodium were crushed and extracted three times at room temperature with chloroform-methanol (1 : 1) and removed by vacuum drying at 40°C.