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茶碱对呼吸系统有6个主要作用:①舒张支气管;②增强呼吸驱动;③预防新生儿反复发作性呼吸骤停;④促进支气管内粘液的清除;⑤减少肥大细胞释放介质;⑥扩张肺动脉。大多数人的支气管舒张效应随剂量的增加而增强。茶碱引起支气管舒张的代限血浓度约为10μg/ml,治疗范围的茶碱血浓度为10~20gg/ml。茶碱引起支气管舒张的超效时间长短不一,如给1次静脉负荷量约需15分钟,持续静脉滴注约需120分钟,口服1次量约需120~180分钟.
Theophylline on the respiratory system has six main effects: ① diastolic bronchus; ② enhance respiratory drive; ③ prevent neonatal recurrent respiratory arrest; ④ promote bronchial mucus clearance; ⑤ reduce mast cell release mediators; ⑥ expansion of the pulmonary artery. Bronchodilatory effects in most people increase with dose. Theophylline-induced bronchodilator generation-limiting blood concentration of about 10μg / ml, the theophylline treatment of the blood concentration of 10 ~ 20gg / ml. The theophylline bronchodilator caused by varying the length of time overdose, such as a intravenous load of about 15 minutes, continuous intravenous infusion of about 120 minutes, oral dose of about 120 to 180 minutes.