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目的结合临床高脂血症的分类,对大鼠实验性高脂血症模型进行分析,为更合理地选择高脂血症动物模型提供依据。方法采用高脂饲料喂养法建立大鼠高脂血症模型。观察喂养30d后大鼠体重、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)的变化。结果高脂饲料组大鼠体重比正常对照组低,但差异无显著性(P>0.05);血清TC明显高于对照组,差异有非常显著性(P<0.01);TG、HDL-C明显低于对照组,差异有显著性(P<0.05、P<0.01)。结论高脂膳食不一定导致体重增加;高脂饲料喂养法所建立的大鼠高脂血症模型只符合高胆固醇血症和低高密度脂蛋白血症的特征,其是否只适用于高胆固醇血症和低高密度脂蛋白血症的研究,而不适用于高甘油三酯血症和混合型高脂血症的研究,有待进一步实验证实。
Objective To analyze the experimental hyperlipidemia model in clinical classification of clinical hyperlipidemia and provide the basis for the rational selection of hyperlipemia animal model. Methods Hyperlipidemia model was established by high fat diet. The changes of body weight, serum total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) were observed 30 days after feeding. Results The body weight of rats in high-fat diet group was lower than that in normal control group, but the difference was not significant (P> 0.05). The serum TC level was significantly higher than that in control group (P <0.01). TG and HDL-C were significantly Lower than the control group, the difference was significant (P <0.05, P <0.01). Conclusion High-fat diet does not necessarily lead to weight gain. The model of hyperlipemia in rats fed with high-fat diet only accords with the characteristics of hypercholesterolemia and low-density lipoproteinemia. Is it suitable for hypercholesterolemia Disease and low-density lipoproteinemia research, but not for hypertriglyceridemia and mixed hyperlipidemia study, to be confirmed by further experiments.