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目的 研究小剂量尿激酶颈动脉加压灌注治疗急性脑梗死的效果 方法 选择 80例急性脑梗死住院病人按入院顺序随机分为治疗组 (颈动脉灌注组 )和对照组 ,各 4 0例。治疗组入院后即给予尿激酶 30万单位于患侧颈动脉加压灌注 ,同时给予低分子右旋糖酐 50 0 ml、脉胳宁 2 0 ml、有脑水肿者给予甘露醇、细胞活化剂、钙离子拮抗剂同时应用 ;对照组除尿激酶外用药相同。两组于治疗前及治疗后 1 5天按临床神经功能缺损程度评分标准作出疗效评定 结果 治疗组总有效率为 90 % ,对照组总有效率为70 % ,两组比较有显著性差异 ( P <0 .0 5) 结论 小剂量尿激酶颈动脉灌注治疗急性脑梗死是一种安全、简便易行、疗效可靠的方法 ,若同时与其他药物联用效果可能会更好
Objective To study the effect of low-dose urokinase carotid artery perfusion in the treatment of acute cerebral infarction.Methods Eighty patients with acute cerebral infarction were randomly divided into treatment group (carotid artery infusion group) and control group according to hospital admission order, 40 cases each. The treatment group was given 30,000 units of urokinase in the ipsilateral carotid artery after pressure infusion, while giving low molecular weight dextran 50 0, pulse Ning 20 ml, with brain edema were given mannitol, cell activators, calcium Antagonist at the same time; control group except for urokinase outside the same medication. The two groups before treatment and 15 days after treatment according to the clinical neurological deficit score to make the curative effect evaluation results in the treatment group, the total effective rate was 90%, the control group, the total effective rate was 70%, the two groups were significantly different (P <0 .0 5) Conclusions Low-dose urokinase carotid artery perfusion is a safe, simple and reliable method for the treatment of acute cerebral infarction. If combined with other drugs at the same time, the effect may be better