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本试验被测化合物在其化学合成和化学结构方面有密切关系,并且均属受阻酚类抗氧剂,在工业上有重要用途,其作为高分子聚合物的稳定剂有抗光、热、氧等作用。本研究拟通过致畸试验,了解其对实验动物有无远期危害,如胚胎毒作用和致畸作用等,为保证安全生产提供卫生学资料,并通过比较其远期作用的特点,初步探讨与被测物的化学结构有何关系,为今后深入开展化学结构与毒性的关系的研究积累资料。
The test compounds in the chemical synthesis and chemical structure are closely related, and are hindered phenolic antioxidants, has an important industrial use, as a polymeric polymer stabilizer light, heat, oxygen And so on. This study intends to teratogenic test to understand whether the long-term harm to the experimental animals, such as embryo toxicity and teratogenic effects, to ensure safety in production to provide hygiene information, and by comparing the characteristics of its long-term effects, preliminary study It is related to the chemical structure of the analyte and accumulates data for further research on the relationship between chemical structure and toxicity.