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本工作应用经改进的检测装置和方法,观察了手术切除甲状腺复制的甲低阳虚兔模型整体水平氧耗量的变化以及温补肾阳中药对其的调整作用.实验表明,全切组(甲状腺全切除)、全药组(全切除加用中药)、次切组(甲状腺部分切除)和次药组(甲状腺部分切除加用中药)兔术后20天氧耗量均值较术前分别降低34.43%、19.48%、23.91%和13.99%(P<0.01或<0.02),组间比较差别有非常显著意义(P<0.001).提示动物模型在证候表现,病变实质上与临床阳虚证相近,温补肾阳复方可提高甲低兔能量代谢水平,使全切兔氧耗量达到或超过次切兔水平(P>0.05),使次切兔接近假切对照兔水平(P>0.05),中药调节效应可能是通过促进病损甲状腺的分泌机能和(或)通过甲状腺外的其它调节途径实现的。
In this work, improved detection devices and methods were used to observe the changes in the overall level of oxygen consumption in a rabbit model of hypothyroidism with surgical excision of the thyroid gland, and to adjust the effects of warming kidney-yang herbs on them. Experiments showed that the whole-cut group (thyroid) Total Oxygen Consumption, Total Oxygen Consumption at 20 Days After Complete Regimen (Full Resection plus Chinese Medicine), Subcutaneous Resection (Partial Thyroidectomy), and Subcontractive Regimen (Partial Thyroidectomy plus Traditional Chinese Medicine) Reduced by 34.43. %, 19.48%, 23.91% and 13.99% (P<0.01 or <0.02). There was a significant difference between the two groups (P<0.001). This suggested that the animal model showed signs, and the lesions were essentially similar to the clinical yang deficiency. Warming up the kidney-yang compound can increase the level of energy metabolism in the low-abundance rabbits, so that the total rabbit oxygen consumption reaches or exceeds the level of the second-cut rabbit (P>0.05), so that the sub-cut rabbit approaches the level of the sham-cut rabbit (P>0.05). The regulatory effect of traditional Chinese medicine may be achieved by promoting the secretion of the thyroid gland and/or through other regulatory pathways outside the thyroid gland.