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目的探讨马来酸桂哌齐特治疗短暂性脑缺血发作(TIA)的临床疗效。方法将72例TIA患者随机分为治疗组和对照组各36例,对照组采用马来酸桂哌齐特治疗,治疗组采用复方丹参治疗,观察临床疗效和药物不良反应。结果治疗组总有效率97%,对照组总有效率86%,经统计学处理有极显著性差异(P<0.01);24 h TIA发作控制率72%,明显优于对照组(53%)(P<0.01);治疗期间治疗组发生脑梗死1例(3%),对照组为5例(14%);无明显不良反应。结论马来酸桂哌齐特治疗TIA行之有效,安全系数高,值得临床进一步研究及推广。
Objective To investigate the clinical efficacy of Cinepazide maleate in the treatment of transient ischemic attack (TIA). Methods Seventy-two patients with TIA were randomly divided into treatment group (36 cases) and control group (36 cases). The control group was treated with cinepazide maleate. The treatment group was treated with compound salvia miltiorrhiza. Clinical efficacy and adverse drug reactions were observed. Results The total effective rate was 97% in the treatment group and 86% in the control group, with a statistically significant difference (P <0.01). The 24 h TIA seizure control rate was 72%, significantly higher than that of the control group (53%) (P <0.01). In the treatment group, 1 case (3%) of cerebral infarction occurred in the treatment group and 5 cases (14%) in the control group. There was no obvious adverse reaction. Conclusion Cinepazide maleate is effective in treating TIA with high safety factor, which deserves clinical further study and promotion.