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目的探讨抗菌药物组合轮用策略对多重耐药鲍曼不动杆菌的治疗效果。方法 2012年6月~2014年12月收治的256例多重耐药鲍曼不动杆菌下呼吸道感染患者作为新策略组,2010年1月~2012年5月收治的210例多重耐药鲍曼不动杆菌下呼吸道感染患者作为旧策略组,观察和分析两组患者的治疗效果。结果新策略组治疗有效时间明显短于旧策略组,治疗总有效率明显高于旧策略组,差异均具有统计学意义(P<0.05);新策略组二线抗菌药物耐药率高于旧策略组,但差异无统计学意义(P>0.05)。结论抗菌药物组合轮用策略能提高多重耐药鲍曼不动杆菌下呼吸道感染的治疗效果,保持抗菌药物的敏感性,值得临床治疗中推广使用。
Objective To investigate the therapeutic effect of antibacterial combination round strategy on multidrug-resistant Acinetobacter baumannii. Methods From June 2012 to December 2014, 256 patients with multi-drug resistant Acinetobacter baumannii lower respiratory tract infection were enrolled as new strategy group. From January 2010 to May 2012, 210 multi-drug resistant bowman Patients with lower respiratory tract infection with Acinetobacter baumannii as an old strategy group were observed and analyzed the therapeutic effect of two groups of patients. Results The effective time of the new strategy group was significantly shorter than that of the old strategy group, and the total effective rate of the new strategy group was significantly higher than that of the old strategy group (P <0.05). The second-line antibacterial drug resistance rate of the new strategy group was higher than the old strategy group Group, but the difference was not statistically significant (P> 0.05). Conclusion The combination strategy of antimicrobial agents can improve the therapeutic effect of multidrug-resistant Acinetobacter baumannii lower respiratory tract infection and maintain the sensitivity of antimicrobial agents, which is worth promoting in clinical treatment.