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目的研究氩氦刀冷冻消融术联合节拍化疗治疗巨块型肝癌的临床疗效。方法 60例巨块型肝癌患者,随机分为观察组和对照组,每组30例。观察组在氩氦刀冷冻消融术基础上联合节拍化疗;对照组单纯给予氩氦刀冷冻消融术治疗。比较两组的治疗效果。结果观察组患者的临床治疗总有效率(50.0%)高于对照组(23.3%),差异有统计学意义(P<0.05)。观察组1、2年生存率60.0%、40.0%,高于对照组的30.0%、10.0%,差异均有统计学意义(P<0.05)。两组不良反应发生情况比较差异无统计学意义(P>0.05)。结论氩氦刀冷冻消融术联合节拍化疗是治疗巨块型肝癌的一种安全有效方法 ,值得推广。
Objective To study the clinical efficacy of argon-helium-knife cryoablation combined with beat-temp chemotherapy in the treatment of massive liver cancer. Methods Sixty patients with massive liver cancer were randomly divided into observation group and control group, 30 cases in each group. The observation group was combined with beat chemotherapy on the basis of cryoablation of argon-helium knife; the control group was treated by cryoablation of argon-helium knife alone. Compare the treatment effect of two groups. Results The total effective rate of clinical treatment in observation group (50.0%) was higher than that in control group (23.3%), the difference was statistically significant (P <0.05). The 1-year and 2-year survival rates in the observation group were 60.0% and 40.0%, respectively, which were significantly higher than those in the control group (30.0% and 10.0%, P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusions Cryosurgery with argon-helium knife combined with chemoembolization is a safe and effective method for the treatment of giant-type hepatocellular carcinoma and is worth promoting.