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背景:实验和临床研究证实壳多糖具有减肥和降低血脂的作用,但是因用量较大存在一定的副作用。目的:观察复方壳多糖对生长期大鼠体质量和血脂水平的影响。设计:完全随机化分组实验。地点和材料:80只SPF级别的3～4周龄健康雄性SD大鼠分为4组饲养于四川省卫生管理干部学院具有屏障系统的恒温动物房内,各实验指标检测在本院实验室进行。干预:A组为正常对照组,喂饲基础饲料、B组为高脂对照组,喂饲高脂饲料、C组为壳多糖组,喂饲壳多糖饲料、D组为复方壳多糖组,喂饲复方壳多糖。主要观察指标:饲养4周后检测各组动物体质量等生长发育指标和血清脂质。结果:①体长和尾长:各组动物饲后均有不同程度的增加,尤其是C组犤(17.73±0.99)cm犦明显,与A组犤(16.50±1.03)cm犦和B组犤(16.35±0.74)cm犦差异有显著性意义(P<0.05)。②三酰甘油:B组犤(1.5680±0.3000)mmol/L犦显著高于A犤(0.9404±0.2864)mmol/L犦、D犤(0.6665±0.2567)mmol/L犦和C组犤(0.8629±0.3382)mmol/L犦(P<0.05);D组最低,与A、C组差异也有显著性意义(P<0.05)。③HDL-c和HDL-c/三酰甘油:D组犤分别为(0.6367±0.1223)mmol/L和0.265〗明显增高,与B组犤分别为(0.4821±0.1058)mmol/L和0.200犦、C组犤分别为(0.5213±0.0938)mmol/L和0.209〗比较差异有显著?
BACKGROUND: Experimental and clinical studies have confirmed that chitin has the effects of losing weight and reducing blood lipids, but there are certain side effects due to the higher dosage. Objective: To observe the effect of compound chitin on body weight and blood lipid levels in growing rats. Design: Completely randomized grouping experiments. Location and Materials: 80 healthy male Sprague-Dawley (SDF) grade 3 to 4 week-old male Sprague-Dawley rats were divided into 4 groups and housed in a constant-temperature animal room with a barrier system at the Sichuan Provincial Institute of Health Management. Laboratory tests were performed in the laboratory of the hospital. . Intervention: Group A was a normal control group, fed basal diet, group B was a high-fat control group, fed high-fat diet, group C was chitosan group, fed chitin diet, group D was compound chitosan group, fed Feed compound chitin. MAIN OUTCOME MEASURES: After 4 weeks of feeding, the growth and development indicators such as body weight and serum lipids were measured in each group. RESULTS: 1 Body length and tail length: Animals in each group all had different degrees of increase after feeding, especially in group C (17.73±0.99) cm, and were significantly different from group A (16.50±1.03) cm and group B. There was significant difference (16.35±0.74)cm between the two groups (P<0.05). 2Triacylglycerol: B group 犤(1.5680±0.3000) mmol/L犦 was significantly higher than A犤(0.9404±0.2864) mmol/L犦, D犤(0.6665±0.2567) mmol/L犦 and C group犤(0.8629±) 0.3382)mmol/L犦(P<0.05); Group D was the lowest, and there was significant difference between group A and group C (P<0.05). 3HDL-c and HDL-c/triacylglycerol: Group D was significantly increased (0.6367±0.1223) mmol/L and 0.265〗, respectively, compared with Group B (0.4821±0.1058) mmol/L and 0.200%, respectively. The differences between the groups were (0.5213±0.0938) mmol/L and 0.209”.