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肺炎链球菌是儿童急性中耳炎(AOM)的常见病原菌,儿童AOM约有10％变为复发性中耳炎(rAOM),其中肺炎链球菌6群和19群最常见,约60％的rAOM儿童缺乏肺炎链球菌6A和19F抗体,表现为IgG1和IgG2抗体活性低下。本文选择10例rAOM儿童(1～3岁)及17例非中耳炎倾向的健康儿童(1～2岁9例,2～3岁8例),用酶联免疫(ELISA)方法测定接种14价肺炎链球菌荚膜多糖疫苗前后血清中抗体,包括抗肺炎链球菌6A、19F的IgG1、IgG2、IgG3、IgG4、
Streptococcus pneumoniae is a common pathogen of acute otitis media (AOM) in children, and about 10% of AOMs in children become recurrent otitis media (rAOM), of which pneumococcal flora 6 and 19 are the most common and about 60% of rAOM children lack pneumonia The cocci 6A and 19F antibodies showed low activity of IgG1 and IgG2 antibodies. In this paper, 10 children with rAOM (1 to 3 years old) and 17 children with non-otitis media (9 children aged 1-2 years and 8 children aged 2-3 years) were enrolled in this study. 14-valent pneumonia was vaccinated by enzyme linked immunosorbent assay (ELISA) Streptococcal capsular polysaccharide vaccine before and after serum antibodies, including against Streptococcus pneumonia 6A, 19F IgG1, IgG2, IgG3, IgG4,