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[目的]探讨江苏省扬中市居民饮水及农药使用对食管鳞癌发生的影响。[方法]采用以人群为基础的病例对照研究方法,对扬中市350例食管鳞癌患者和408例按照性别和年龄进行频数匹配的正常对照进行标准化问卷调查,在控制性别、年龄、吸烟和饮酒等潜在混杂因素后,运用非条件Logistic回归方法分析当地居民饮水及农药使用与食管鳞癌的关系。[结果]既往有直接饮用未处理的河沟水史(OR=1.79,95%CI:1.23～2.61)、居住地周围有水污染相关企业(OR=1.58,95%CI:1.10～2.25),以及经常使用农药(OR=1.70,95%CI:1.24～2.32)尤其是有机氯农药(OR=2.55,95%CI:1.67～3.91)与食管鳞癌发病危险有关。[结论]饮用污染水和农药使用可能与当地居民食管鳞癌高发有关。
[Objective] To investigate the influence of drinking water and pesticide use on the occurrence of esophageal squamous cell carcinoma in Yangzhong City, Jiangsu Province. [Methods] A population-based case-control study was conducted to investigate the relationship between sex, age, smoking and drinking in 350 cases of esophageal squamous cell carcinoma in Yangzhong city and 408 normal controls matched by frequency and age. And other potential confounding factors, the use of unconditional Logistic regression analysis of local residents drinking water and pesticide use and esophageal squamous cell carcinoma relationship. [Results] There was a history of direct drinking of untreated river water (OR = 1.79, 95% CI: 1.23-2.61), water polluting enterprises (OR = 1.58, 95% CI: 1.10-2.25) Frequent use of pesticides (OR = 1.70, 95% CI: 1.24-2.32) and especially organochlorine pesticides (OR = 2.55, 95% CI: 1.67-3.91) were associated with the risk of esophageal squamous cell carcinoma. [Conclusion] Drinking contaminated water and pesticide use may be related to the high incidence of esophageal squamous cell carcinoma in local residents.