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本文测定14例不稳定型心绞痛(UA)、12例稳定劳力型心绞痛(SA)和12例健康人的血小板功能和纤溶活性。结果表明,无心绞痛发作时,UA组,SA组的血小板聚集率(PAg)、血栓素B2(TXB2)和纤溶酶原激活剂的抑制剂(PAI)活性均比健康对照组明显增加,但UA组与SA组间无明显差异;UA组和SA组的血浆组织型纤溶酶原激活剂(t-PA)活性均明显低于健康对照组,且UA组比SA组降低更明显,UA组在心绞痛发作时,上述指标的变化无显著性差异。本文提示,不稳定型心绞痛患者血栓形成的主要因素可能为t-PA的活性降低。
This article measured platelet function and fibrinolytic activity in 14 patients with unstable angina (UA), 12 patients with stable angina pectoris (SA) and 12 healthy individuals. The results showed that the activities of platelet aggregation (PAg), thromboxane B2 (TXB2) and plasminogen activator inhibitor (PAI) in UA group and SA group were significantly higher than those in healthy control group UA group and SA group no significant difference; UA group and SA group plasma tissue-type plasminogen activator (t-PA) activity were significantly lower than the healthy control group, and the UA group was significantly lower than the SA group, UA Group angina attacks, the above indicators did not change significantly. This article suggests that the main factor in thrombosis in patients with unstable angina may be reduced t-PA activity.