论文部分内容阅读
目的观察黄芪注射液对应激状态下大鼠胃黏膜损伤有无保护作用。方法采用水浸束缚应激方法复制大鼠应激性溃疡模型。将40只健康大鼠随机分为5组:对照组、模型组、黄芪10g/kg、20 g/kg 组和硫糖铝500 mg/kg 给药组。分别连续灌胃给予黄芪或硫糖铝5 d 后复制模型,6 h 后取胃计算溃疡指数,采用光镜观察大鼠胃组织病理改变。结果水浸束缚应激致应激性溃疡形成,胃黏膜出现广泛的糜烂、出血。黄芪和硫糖铝均可显著降低溃疡指数(P<0.01),其中黄芪20g/kg 疗效最佳,优于硫糖铝500 mg/kg(P<0.05)。黄芪可显著减轻大鼠胃黏膜细胞损伤程度和毛细血管及其周围间质的水肿。结论黄芪对应激性溃疡大鼠具有显著的胃黏膜保护作用。
Objective To observe whether Astragalus injection has a protective effect on gastric mucosal injury under stress. Methods The model of stress ulcer was reproduced by immersion restraint stress method. Forty healthy rats were randomly divided into five groups: control group, model group, astragalus 10g / kg, 20g / kg group and sucralfate 500mg / kg group. The rats were respectively intragastrically given Astragalus membranaceus or sucralfate for 5 days, then the model was duplicated. After 6 hours, the gastric ulcer index was calculated. The pathological changes of gastric tissue were observed with light microscope. The results of stress caused by flooding restraint stress ulcer formation, gastric mucosa showed extensive erosion, bleeding. Astragalus and sucralfate significantly reduced the ulcer index (P <0.01), of which Astragalus 20g / kg was the best, which was superior to sucralfate 500 mg / kg (P <0.05). Astragalus can significantly reduce the degree of gastric mucosal injury in rats and the capillary and its surrounding edema. Conclusion Astragalus has a significant gastric mucosal protective effect on stress ulcer rats.