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目的探讨125I粒子置入治疗肺癌脑转移瘤的临床意义和可行性。方法对63例肺癌脑转移瘤患者分为两组,其中125I粒子置入组45例,传统手术组18例。观察两组患者术后肿瘤局部控制情况及生存时间。结果立体定向置入125I粒子组和传统手术组比较,前者并发症少,新发颅内转移灶时间延长,生存时间增加,生存率明显提高,后者易出现肿瘤复发。结论立体定向置入125I粒子治疗肺癌脑转移瘤可延长患者生存时间,提高患者生存质量。
Objective To investigate the clinical significance and feasibility of 125I particle implantation in the treatment of brain metastases of lung cancer. Methods Sixty-three patients with brain metastases of lung cancer were divided into two groups, of which 45 cases were treated with 125I particles and 18 cases were treated with conventional surgery. The local tumor control and survival time of the two groups were observed. Results Stereotactic 125I implantation group compared with the traditional surgery group, the former less complications, new intracranial metastases, prolonged survival time, survival rate was significantly improved, the latter prone to tumor recurrence. Conclusion The stereotactic implantation of 125I particles in the treatment of brain metastases of lung cancer patients can prolong the survival time and improve the quality of life of patients.