目的:观察消瘀片对实验性高血脂症兔的治疗作用。方法:雄性新西兰兔高脂饲养8周形成实验性高血脂症,然后分组连续给予消瘀片12周,测定给药后6和12周时的血脂变化。结果:消瘀片0.16～0.32g/(kg·d)口服6～12周后,可使血清TC、TC、LDL-C和apoB含量明显降低,apoAI/apoB比值升高,尤其大剂量组的作用更为显著,单味中药丹参或山楂提取物的降血脂作用不如消瘀片。结论:消瘀片对已形成的高血脂症兔具有明显的降血脂作用。 Objective: To observe the therapeutic effect of Xiaoyu Tablet on experimental hyperlipidemic rabbits. METHODS: Male New Zealand rabbits were fed with high-fat diet for 8 weeks to form experimental hyperlipidemia, and then subgroups were given continuous Xiaoqi tablets for 12 weeks. Changes in blood lipids at 6 and 12 weeks after administration were measured. RESULTS: After oral administration of 0.16-0.32g/(kg·d) for 6-12 weeks, the serum levels of TC, TC, LDL-C and apoB were significantly reduced, and the ratio of apoAI/apoB was increased, especially in the high-dose group. The effect was even more pronounced, and the lipid-lowering effect of single Chinese medicine Salvia miltiorrhiza or hawthorn extract was not as good as that of Xiaoying tablets. Conclusion: Xiaoyu Tablet has obvious hypolipidemic effect on the hyperlipidemia rabbits.