特拉唑嗪(Terazosin)是一种新的选择性α_1-肾上腺素能受体阻滞剂,其结构和作用类似哌唑嗪(Prazosin),见图。研究表明,特拉唑嗪是一种有效的降压药,单用或与其它药物合用均可,近来,食品及药物管理局(FDA)批准本药用于治疗高血压。一、作用部位及机制特拉唑嗪对高血压病人的扩血管作用类似于哌唑嗪,是由选择性阻滞了外周突触后膜的α_1-肾上腺素能受体而引起的。动物研究表明,静脉用特拉唑嗪,通过降低外周血 Terazosin is a new, selective α 1 -adrenoceptor blocker whose structure and action is similar to that of Prazosin, see figure. Studies have shown that terazosin is an effective antihypertensive drug, either alone or in combination with other drugs, recently approved by the Food and Drug Administration (FDA) for the treatment of hypertension. First, the role of site and mechanism Terazosin vasodilator effect on hypertensive patients similar to prazosin, is a selective block peripheral postsynaptic membrane α 1 -adrenoceptor caused. Animal studies have shown that intravenous terazosin, by reducing peripheral blood