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目的观察瑞舒伐他汀对2型糖尿病并颈动脉粥样硬化(CAS)斑块患者的临床疗效。方法对70例2型糖尿病合并CAS斑块患者采用常规疗法加瑞舒伐他汀治疗。治疗前后检测其血脂及血清C反应蛋白(CRP),用彩超检查颈动脉内膜-中层厚度(IMT)及颈动脉斑块、数量变化。结果治疗后6个月,患者血脂明显改善,双侧颈动脉IMT明显降低、颈动脉斑块明显缩小(P<0.05)。结论瑞舒伐他汀可有效地降低2型糖尿病并CAS斑块患者的血脂及血清CRP,可显著改善2型糖尿病患者动脉硬化程度,对粥样硬化斑块起稳定作用。
Objective To observe the clinical effect of rosuvastatin on type 2 diabetic patients with carotid atherosclerosis (CAS) plaque. Methods 70 patients with type 2 diabetes mellitus and CAS plaque were treated with conventional therapy and rosuvastatin. The levels of serum lipids and serum C-reactive protein (CRP) were measured before and after treatment. The carotid intima-media thickness (IMT) and carotid artery plaque were examined by color Doppler. Results At 6 months after treatment, the blood lipids were significantly improved in patients with bilateral carotid artery IMT was significantly reduced carotid plaque was significantly reduced (P <0.05). Conclusion Rosuvastatin can effectively reduce the blood lipid and serum CRP in patients with type 2 diabetes mellitus and CAS plaque, and can significantly improve the degree of atherosclerosis in type 2 diabetic patients and stabilize the atherosclerotic plaque.