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目的 探讨一氧化氮 (NO)配合治疗难治性呼衰的疗效。 方法 经机械通气治疗无好转或进行性恶化 ,采用经气道吸入NO治疗严重呼衰患儿 3例 ,浓度为 5～ 2 0ppm ,给患儿持续吸入。 结果 治疗后 3例脉搏氧饱和度 (SPO2 )均有好转 ,呼吸顺应性改善 ,肺水肿好转。未发现明显不良反应。 结论 吸入NO可明显改善低氧性呼衰的SPO2 ,且起效快 ,适宜用于难治性呼衰的治疗。
Objective To investigate the efficacy of nitric oxide (NO) in the treatment of refractory respiratory failure. Methods There was no improvement or worsening of mechanical ventilation after treatment. Three cases of severe respiratory failure were treated by airway inhalation of NO, with a concentration of 5 ~ 20ppm, and the patients were continuously inhaled. Results After treatment, 3 cases of pulse oxygen saturation (SPO2) improved, respiratory compliance improved, pulmonary edema improved. No obvious adverse reactions were found. Conclusion NO inhalation can significantly improve the hypoxemic respiratory failure SPO2, and rapid onset, suitable for treatment of refractory respiratory failure.