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本文报告碘化二甲基木防己碱(DTI)降压作用的研究。DTI给麻醉动物静脉注射,对狗0.05～0.1 mg/kg使血压下降42.3～61.5%,持续1小时左右恢复至原血压水平;对猫0.00625～0.0125 mg/kg使血压下降26.5～43.5%,持续2～4小时恢复至原血压水平;对兔0.005～0.01 mg/kg使血压下降24.3～61.0%,5小时不能恢复至原血压水平;0.5～1.0 mg/kg使大鼠血压下降27.2～41.1%。DTI的降压作用机制主要与其对神经节的阻断作用有关。本药对小鼠口服和静注的LD_(50)分别为522.0 mg/kg及2.23 mg/kg。
This article reports the study of antihypertensive effects of dimethyl tetrahydroiodide iodide (DTI). DTI anesthesia animal intravenous injection of 0.05 ~ 0.1 mg / kg dog blood pressure decreased 42.3 ~ 61.5% for about 1 hour to restore the original blood pressure level; cats 0.00625 ~ 0.0125 mg / kg so that blood pressure decreased 26.5 ~ 43.5%, sustained 2 to 4 hours to restore the original blood pressure levels; rabbit 0.005 ~ 0.01 mg / kg to blood pressure decreased 24.3 ~ 61.0%, 5 hours can not be restored to the original blood pressure levels; 0.5 ~ 1.0 mg / kg decreased blood pressure in rats 27.2 ~ 41.1% . The mechanism of antihypertensive effect of DTI is mainly related to its blocking effect on ganglia. The LD_ (50) of the drug for mice oral and intravenous injection were 522.0 mg / kg and 2.23 mg / kg respectively.