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庆大霉素的疗效及毒性与其在血清中的药物浓度(以下简称血药浓度)有关。研究庆大霉素药物动力学时,用静脉滴注给药法,可简化为单室模型处理,采用下列公式计算血药浓度的经时变化:
The efficacy and toxicity of gentamicin are related to its concentration in serum (hereinafter referred to as plasma concentration). Study of gentamicin pharmacokinetics, intravenous drip method, can be simplified as a single-chamber model, the use of the following formula to calculate the change of blood concentration over time: