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目的探讨脑卒中后抑郁的发生率、相关因素及临床疗效。方法采用汉密尔顿抑郁量表(HAMD)、改良的爱丁堡斯堪地纳维亚神经功能缺损评分量表(SSS)及其他自制相关情况调查表对102例脑卒中急性期住院患者进行调查评分。结果脑卒中后抑郁的总发生率为35.3%。脑卒中后出现抑郁者与脑卒中后无抑郁者比较性别、卒中性质、病变部位无明显差别。但卒中后神经功能缺损的患者抑郁发生率比无神经功能缺损的患者明显增高(P<0.05)。36例卒中后抑郁患者用氟西汀治疗,随访6周,汉密尔顿抑郁量表评分下降者33例(91.7%)。结论脑卒中后抑郁发生率高。其发生与神经功能缺损相关,采用氟西汀治疗有效。
Objective To investigate the incidence of post-stroke depression, related factors and clinical efficacy. Methods A total of 102 in-hospital acute stroke patients were scored by Hamilton Depression Rating Scale (HAMD), Modified Scandinavian Neural Deficit Rating Scale (SSS) and other self-made questionnaires. Results The overall incidence of post-stroke depression was 35.3%. Post-stroke depression compared with those without depression after stroke compared sex, stroke nature, no significant difference in the lesion site. However, the incidence of depression in patients with neurological deficits after stroke was significantly higher than those in patients without neurological deficits (P <0.05). Thirty-six patients with post-stroke depression were treated with fluoxetine. After 6 weeks of follow-up, 33 patients (91.7%) had a decrease in the Hamilton Depression Rating Scale. Conclusion The incidence of post-stroke depression is high. Its occurrence and neurological deficits, the use of fluoxetine treatment effective.