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临床上发现部分卵巢早衰者有自身免疫反应过强现象，外周血可测得抗卵巢抗体（ＡＯＡ）的存在。亦有报道病理检测部分闭经或月经不调患者之卵巢，发现有淋巴细胞浸润，诊断为自身免疫性卵巢炎。鉴于人体在体研究的限制性，故设计建立小鼠自身免疫性卵巢衰退动物模型，拟产生相
Clinically found that some premature ovarian failure have an autoimmune reaction too strong phenomenon, the presence of anti-ovarian antibodies (AOA) can be measured in peripheral blood. There are also reports of pathological detection of amenorrhea or irregular menstruation in patients with ovarian and found that infiltration of lymphocytes, the diagnosis of autoimmune oophoritis. In view of the limitations of human body in vivo research, it is designed to establish an animal model of mouse autoimmune ovarian failure, to be produced phase