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目的:通过对BPH合并Ⅲ_B型前列腺炎组织的病理学分析,探讨老年患者Ⅲ_B型前列腺炎的病理特点与可能的发病机制。方法:选取就诊于我院并行TURP术的BPH患者412例,术前经实验室与临床检查,筛选出合并Ⅲ_B型前列腺炎患者66例,并行TURP,术后前列腺组织根据Nickel前列腺炎症程度和主要炎症类型的诊断标准进行病理分型与分级的对比研究。结果:66例BPH并Ⅲ_B型前列腺炎患者经病理检查证实合并不同程度炎症,主要以基质与腺周炎症浸润为主。根据不同病理类型分为腺体炎组、基质炎组、腺周炎组,比较三组炎症程度分布(G_1为轻度,G_2/G_3为中重度)及分级情况,差异有统计学意义(P<0.05)。腺体炎与基质炎、腺周炎比较,差异有统计学意义(P<0.01);腺周炎与基质炎比较,差异无统计学意义(P>0.05)。结论:老年患者Ⅲ_B型前列腺炎患病率较高,病理炎症较重,炎细胞主要浸润前列腺腺周与基质,为腺周炎与基质炎,梗阻可能是其重要发病因素之一。
Objective: To investigate the pathological features and possible pathogenesis of type Ⅲ_B prostatitis in elderly patients by pathological analysis of BPH combined with type Ⅲ_B prostatitis. Methods: Forty-one patients with BPH who were treated with TURP in our hospital were selected. Totally 66 patients with type Ⅲ_B prostatitis were screened preoperatively by laboratory and clinical examination. TURP was performed. The postoperative prostate tissue was selected according to the degree of Nickel prostatitis and the main The diagnostic criteria for the type of inflammation were compared for pathological classification and grading. Results: 66 cases of BPH and Ⅲ_B prostatitis patients confirmed by pathological examination with varying degrees of inflammation, mainly infiltration of stromal and perirenal inflammation based. According to the different pathological types, we divided them into glanditis group, stromal inflammation group and glandularis group, and compared the distribution of inflammation degree (G_1 was mild, G_2 / G_3 was moderate and severe) and grading, the difference was statistically significant (P <0.05). There was significant difference between glandular inflammation and gingivitis and glandular inflammation (P <0.01). There was no significant difference between glandular inflammation and stromal inflammation (P> 0.05). Conclusion: Elderly patients with type Ⅲ_B prostatitis higher prevalence, severe pathological inflammation, inflammatory cells mainly infiltration of the prostate gland and stroma, glandular inflammation and stromal inflammation, obstruction may be one of the important risk factors.