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本文仅从动脉壁胆固醇酯(CE)沉积方面,对cAMP 与动脉粥样硬化形成的关系作一讨论。一、cAMP 与血浆脂质1.cAMP 与甘油三酯(TG):血浆脂质主要来自食物的消化吸收和体内合成。合成过程大致为:储存于脂肪组织中的TG 在激素敏感脂酶的作用下分解,释放游离脂肪酸(FFA)。FFA 被转运至肝脏,合成TG,并与磷脂、CE 及载脂蛋白结合在一起,构成极低密度脂蛋白(VLDL),释放入血。在血中,VLDL 又受血管壁脂蛋白脂酶(LPL)的作用,释放FFA,并进入组织细胞。儿茶酚胺可与脂肪组织的β受体结合,
This article discusses the relationship between cAMP and atherosclerosis only in terms of arterial wall cholesterol ester (CE) deposition. First, cAMP and plasma lipid 1.cAMP and triglyceride (TG): plasma lipid mainly from food digestion and absorption and in vivo synthesis. The synthetic process is roughly as follows: The TG stored in adipose tissue is decomposed by hormone-sensitive lipase to release free fatty acid (FFA). FFA is transported to the liver, synthesizes TG, and binds with phospholipids, CE, and apolipoproteins to form very low density lipoproteins (VLDL), which are released into the bloodstream. In the bloodstream, VLDL, in turn, is activated by vascular lipoprotein lipase (LPL), releasing FFA and entering the tissue cells. Catecholamines bind to the beta receptors of adipose tissue,