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作者利用复合致痛剂引起大鼠尾部皮肤多觉型伤害性感受器（ＰＭＮ）持续性放电模型，经股静脉注入吗啡（４ｍｇ／ｋｇ），显著抑制ＰＭＮ持续性放电．吗啡抑制ＰＭＮ放电５０％的潜伏期为１０±４．５ｍｉｎ，抑制时程超过３０ｍｉｎ，纳络酮１ｍｇ／ｋｇｉｖ，可翻转吗啡的抑制作用。在慢性吗啡耐受大鼠，吗啡几乎失去其抑制作用。吗啡引起的ＰＭＮ放电数变化与血压变化不呈一致关系．小剂量吗啡（１ｍｇ／ｋｇ）注入支配感受野皮肤的尾动脉可显著抑制ＰＭＮ持续性放电，但同样剂量全身给药（经股静脉）则无效．结果提示吗啡可通过外周阿片受体抑制大鼠尾部皮肤ＰＭＮ持续性放电．
The authors used the compound sachet to induce PMN persistent discharge in the caudal skin of rats, and morphine (4mg / kg) injected into the femoral vein significantly inhibited PMN persistent discharge. Morphine inhibition PMN discharge 50% of the incubation period of 10 ± 4.5min, inhibit the course of more than 30min, naloxone 1mg / kgiv, morphine can flip the inhibitory effect. In chronic morphine-tolerant rats, morphine almost lost its inhibitory effect. Morphine-induced changes in the number of PMN discharge and blood pressure does not show a consistent relationship. Small doses of morphine (1 mg / kg) injected into the dorsal artery that dominated the sensory field significantly inhibited PMN persistent discharge, but systemic administration of the same dose (via the femoral vein) was ineffective. The results suggest that morphine can inhibit persistent discharge of PMN in the rat caudal skin via peripheral opioid receptors.