论文部分内容阅读
目的:探讨冠心病患者血浆瘦素(leptin,Lep)及可溶性瘦素受体(soluble leptin receptor,sLR)水平的变化,并分析Lep与冠心病各危险因素的关系。方法:选取冠心病患者180例,正常对照组60例。所有患者行冠脉造影检查,冠脉狭窄程度采用Genisin评分,酶联免疫法测定Lep、sLR浓度,同时检测总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、体质量指数(BMI)、腰围、臀围等指标,分析Lep、sLR与冠心病的的关系。结果:冠心病患者lep水平显著高于对照组[(12±6)vs.(9±5)μg/L,P<0.01],sLR水平显著低于对照组[(124±62)vs.(164±70)μg/L,P<0.01],在调整年龄、血糖和血压后,两组间的差别有显著性意义。多元Logistic回归分析显示冠心病患者μg/L。Lep水平的升高独立于年龄、血压、血脂等危险因素。结论:冠心病患者Lep水平与冠脉病变的严重程度呈正相关,而sLRs水平与冠脉病变严重程度呈负相关。
Objective: To investigate the changes of plasma leptin (Lep) and soluble leptin receptor (sLR) levels in patients with coronary heart disease and to analyze the relationship between Lep and risk factors of coronary heart disease. Methods: 180 patients with coronary heart disease and 60 normal controls were enrolled. All patients underwent coronary angiography, Coronary stenosis degree using Genisin score, enzyme linked immunosorbent assay Lep, sLR concentration, simultaneous detection of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C ), LDL-C, body mass index (BMI), waist circumference, hip circumference and other indicators, analysis of Lep, sLR and coronary heart disease. Results: The lep level in patients with coronary heart disease was significantly higher than that in the control group [(12 ± 6) vs. (9 ± 5) μg / L, P <0.01], and the level of sLR was significantly lower than that in the control group [(124 ± 62) vs. 164 ± 70) μg / L, P <0.01]. After adjusting for age, blood glucose and blood pressure, the difference between the two groups was significant. Multivariate Logistic regression analysis showed that patients with coronary heart disease in μg / L. Lep levels increased independently of age, blood pressure, blood lipids and other risk factors. Conclusion: There is a positive correlation between the level of Lep in coronary heart disease and the severity of coronary artery disease, while the level of sLRs is negatively correlated with the severity of coronary artery disease.