核酸是荷载遗传信息的大分子,具有抗原性和免疫原性。1957年有人最先从一种自身免疫病——全身性红斑狼疮(SLE)病人血清内发现天然抗DNA抗体。引起SLE最重要的免疫学因素是体内产生抗各种组织的自身免疫抗体,特别是抗核抗体,造成对白休各种组织细胞的破坏, Nucleic acids are macromolecules that carry genetic information and are antigenic and immunogenic. In 1957, some people first found a natural anti-DNA antibody in the serum of a patient with systemic autoimmune disease-systemic lupus erythematosus (SLE). The most important immunological factors that cause SLE are the autoimmune antibodies against various tissues in vivo, in particular, anti-nuclear antibodies, resulting in the destruction of white tissue cells of various kinds,