论文部分内容阅读
目前,对局部晚期直肠癌患者常在术后行同期新辅助放化疗,但是其风险程度和治疗结果并不尽人意。鉴于谷氨酰胺代谢在肿瘤中常常改变,Lee YY等人集中研究了与谷氨酰胺代谢过程相关的基因(GO:0006541)并发现氨甲酰磷酸合成酶1(CPS1)基因表达上调可预测同期放化疗的不良反应。他们用免疫组织化学法对172例直肠癌患者由结肠镜检查得到的肿瘤样本进行分析。结果发现,CPS1的表达水平与主要临床病理特征以及存活率相关。为进一步确认CPS1的表达水平,研究者
Currently, patients with locally advanced rectal cancer often undergo concurrent neoadjuvant chemoradiation after surgery, but the degree of risk and treatment results are not satisfactory. Since glutamine metabolism is often altered in tumors, Lee YY et al focused on the genes involved in glutamine metabolism (GO: 0006541) and found that up-regulation of carbamoyl-phosphate synthase 1 (CPS1) gene can predict the same Adverse reactions to radiotherapy and chemotherapy. They used immunohistochemistry to examine 172 colon cancer samples from colon cancer patients. The results showed that the expression level of CPS1 correlated with the main clinicopathological features and survival rate. To further confirm the expression level of CPS1, researchers