目的探讨空腹胰高血糖素(Glg)与2型糖尿病患者肝肾功能的相关性。方法 135例2型糖尿病患者按空腹Glg水平分为正常组(20~120pg/ml)、中高组(120~200pg/ml)和高组(>200pg/ml),比较三组肝肾功能相关指标,并行相关因素分析。结果白蛋白、AST、GGT、BUN、Cr、UA、估算肾小球滤过率(eGFR)、空腹Glg与空腹C肽和FBG比值随空腹Glg水平升高而升高(P<0.05);空腹Glg与GGT、空腹C肽、空腹Glg与空腹C肽和FBG比值呈正相关(r=2.16、0.18、0.05、0.90,P<0.05)。多元逐步回归分析结果显示,FBG、GGT、BMI及空腹Glg与FBG比值为空腹Glg独立影响因素(P<0.05)。结论空腹Glg影响2型糖尿病患者肝肾功能,抑制Glg药物在降糖基础上有可能保护患者肝肾功能。 Objective To investigate the relationship between fasting glucagon (Glg) and liver and kidney function in type 2 diabetic patients. Methods One hundred and thirty-five patients with type 2 diabetes were divided into normal group (20-120pg / ml), middle-high group (120-200pg / ml) and high group (> 200pg / ml) according to their fasting Glg levels. , Parallel analysis of relevant factors. Results The ratios of albumin, AST, GGT, BUN, Cr, UA, estimated glomerular filtration rate (eGFR), fasting Glg and fasting C-peptide and FBG increased with fasting Glg level (P < Glg and GGT, fasting C-peptide, fasting Glg and fasting C-peptide and FBG ratio was positively correlated (r = 2.16,0.18,0.05,0.90, P <0.05). Multiple stepwise regression analysis showed that FBG, GGT, BMI and fasting Glg to FBG ratio were independent factors of fasting Glg (P <0.05). Conclusion Fasting Glg affects liver and kidney function in patients with type 2 diabetes and suppresses Glg drugs on the basis of hypoglycemic effect, which may protect liver and kidney function of patients.