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作者测定了各种肝病患者血清中Ⅲ型溶胶元N-肽(Type ⅢProcollagen N-Peptide)(P-Ⅲ-P)的浓度,探讨了它的临床意义。对象及方法:选择不同肝病住院患者191例,并以15例健康人做对照,测定了血清P-Ⅲ-P浓度。早晨空腹采血,-40℃保存血清。按Rohde氏法测定。结果:健康人平均值9.90±2.60ng/ml。将15ng/ml以上(平均值+2S.D.作为异常值。) 急性肝炎35例,A型(12例):28.31±33.70ng/ml。B型(13例):40.00±32.07ng/ml。非A非B型(8例):13.30±8.46ng/ml。急性肝炎发病初期和发病一段时间比较,P-Ⅲ-P在发病初期呈现高值。以后,随着GPT活性下降而急剧下降。慢性肝炎(52例);平均值19.31±12.27ng/ml。25例肝活检发现:慢性活动性肝炎39.96±29.
The authors measured the serum concentration of Type III Pollagen N-Peptide (P-III-P) in patients with various liver diseases and discussed its clinical significance. Subjects and Methods: A total of 191 inpatients with different liver diseases were selected and compared with 15 healthy controls. The serum P-III-P concentration was measured. Fasting blood in the morning, save serum at -40 ℃. According to Rohde’s method. Results: The average healthy person was 9.90 ± 2.60ng / ml. Thirty-five patients were acute hepatitis with a mean of 15 ng / ml or more (mean + 2S.D.), type A (12 cases): 28.31 ± 33.70 ng / ml. Type B (13 cases): 40.00 ± 32.07 ng / ml. Non-A non-B type (8 cases): 13.30 ± 8.46 ng / ml. Early onset of acute hepatitis and onset of a period of time, P-Ⅲ-P in the early stages of the disease showed high values. Later, the GPT activity dropped sharply. Chronic hepatitis (52 cases); mean 19.31 ± 12.27 ng / ml. 25 cases of liver biopsy found: chronic active hepatitis 39.96 ± 29.