全身型巨细胞包涵体病少见。我们婴检发现1例,现报告如下。患儿,男,年龄3天,第1胎,孕35周。出生时评5分,经人工呼吸、吸痰、给氧后,仍呼吸困难、紫绀,伴烦燥不安、尖叫,于生后3天心跳,呼吸停止,死亡。其母既往体健,未提供妊娠期间有否感染史。尸检所见:死婴身长52cm,营养欠佳,发育差。尸冷、尸僵及尸斑存在。全身皮肤及巩膜轻度黄染,表浅淋巴结均未触及,口、鼻、外耳道见少许淡红色分泌物溢出。肺脏:左肺三叶,大小约7×4×2 cm~3;右肺三叶,大小约6×4×1.5cm。紫红色,手挤压可有血性液体流出。镜下,肺泡上皮细胞肿大。见巨细胞夹在肺泡上皮细胞之间,体积相当于正常上皮细胞的3～4倍,胞浆略嗜碱,有的呈空泡状;胞核相应增大,但核浆比例仍正常。于胞浆内或核内可见包涵 Systemic giant cell inclusion disease rare. We found a baby examination, are as follows. Children, male, age 3 days, the first child, 35 weeks pregnant. 5 points at birth, after artificial respiration, suction, oxygen, still breathing difficulties, cyanosis, with irritability, screaming, 3 days after birth, heartbeat, respiratory arrest, death. Her mother past physical health, did not provide any history of pregnancy during pregnancy. Autopsy see: dead baby body length 52cm, poor nutrition, poor development. Dead body, dead dead and dead spots exist. Slightly yellowish body skin and sclera, superficial lymph nodes were not touched, mouth, nose, external auditory canal, see a little pink discharge overflow. Lung: Left lung clover, the size of about 7 × 4 × 2 cm ~ 3; right lung clover, the size of about 6 × 4 × 1.5cm. Fuchsia, hand squeeze may have bloody fluid outflow. Microscope, alveolar epithelial cells enlarged. See giant cells sandwiched between alveolar epithelial cells, the volume is equivalent to normal epithelial cells 3 to 4 times, cytoplasm slightly basophilic, and some were vacuolar; nucleus corresponding increase, but the proportion of nuclear plasma is still normal. Inclusion in the cytoplasm or nucleus can be seen