对80例神经型地方性克汀病人进行了神经系统检查,同时对其中10例进行了脑 CT 研究。结果发现病人神经系统变化的谱带很宽,除了智力、语言、听力障碍外,还有肢体痉挛和强直,尤以下肢近端为著。典型的锥体外系受损表现,额叶释放征,木僵状态,感觉迟钝等。脑CT 主要变化为,脑 CT 值偏低,不同程度皮质指压痕样切迹,蛛网膜下腔开大,脑池增宽,脑内有点状钙化等。此外,本文还结合动物实验,尸解材料,讨论了临床表现与脑损害的定位关系。 Nervous system tests were performed on 80 patients with neurocrine cretinism and 10 of them underwent brain CT studies. The results showed that patients with a wide range of changes in the nervous system, in addition to intelligence, language, hearing impairment, there is limb spasticity and rigidity, especially in the proximal lower extremity. Typical extrapyramidal impaired performance, frontal lobe sign, stiff state, feeling insensitive and so on. The main changes of brain CT, brain CT value is low, varying degrees of cortical finger indentation notch, a large subarachnoid space, brain pool broadening, a bit calcified brain. In addition, this article also combined animal experiments, autopsy material, discusses the clinical manifestations and the relationship between brain damage.