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本文探讨卡托普利对常规治疗下的严重充血性心力衰竭(CHF)是否有效,而且联合应用螺旋内酯、小剂量卡托普利和大剂量襻利尿剂是否安全。共124例住院患者,男92例、女32例,平均年龄68(39～84)岁,心衰平均持续时间33(2～120)个月。其中缺血性心脏病84例,高血压24例,扩张型心肌病12例,二尖瓣返流4例。43例已作常规扩血管治疗,但因效果不佳而停用。开始本试验时,所有患者均服用速尿(平均剂量170mg/d)。117例加用洋
This article investigates whether captopril is effective in patients with severe congestive heart failure (CHF) under conventional therapy and whether combination of spironolactone, low-dose captopril, and high-dose loop diuretics is safe. A total of 124 inpatients, 92 males and 32 females, with an average age of 68 (39 to 84) years old, the average duration of heart failure 33 (2 to 120) months. Including 84 cases of ischemic heart disease, hypertension in 24 cases, dilated cardiomyopathy in 12 cases, 4 cases of mitral regurgitation. 43 cases of conventional vasodilator have been treated, but because of ineffective and disabled. At the beginning of this test, all patients took furosemide (mean dose 170 mg / d). 117 cases plus ocean