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充血性心衰(CHF)病人病死率高且需反复住院治疗。本文在慢性CHF、射血分数低于0.35的病人中研究了转换酶抑制剂苯脂丙脯酸对病死率和住院次数的影响。方法心衰常规治疗病人随机双盲分组,接受安慰剂(1284例)或每日 2.5～20mg剂量苯脂丙脯酸(1285例)治疗。大约90％的病人NYHA心功能分级为Ⅱ至Ⅲ级。平均随访41.4个月。
Patients with congestive heart failure (CHF) have a high case fatality rate and require repeated hospitalizations. In this paper, chronic CHF, ejection fraction lower than 0.35 in the study of the conversion enzyme inhibitor phentermine on mortality and hospitalization frequency. Methods Patients with conventional therapy of heart failure were randomized to double-blind treatment with either placebo (1284 patients) or daily diphenolazepin (1285 patients) at doses of 2.5 to 20 mg. Approximately 90% of patients with NYHA cardiac function grade Ⅱ to Ⅲ grade. The average follow-up was 41.4 months.