作者在超声引导下将不同剂量~(90)Y玻璃微球(~(90)Y GM)注入兔肝内,以观察局部注射后同位素的体内分布及注射区肝脏的组织学变化.结果表明,该方法同位素微球仅局限于注射区内.韧致辐射范围4.1～12.55cm~2(平均8.45cm~2),未发现肝外分流及非靶器官损伤.注射剂量35mci时可致辐射区内肝细胞完全坏死.本研究表明该方法微球定位准确,可致局部高辐射能,因而可望成为非手术治疗肝癌的手段之一. The authors injected different doses of ~ (90) Y glass microspheres (~ (90) Y GM) into the liver of rabbits under ultrasound guidance to observe the in vivo distribution of the isotope after injection and the histological changes in the liver of the injection area. The method of isotope microspheres is confined to the injection zone, bremsstrahlung range of 4.1 ~ 12.55cm ~ 2 (average 8.45cm ~ 2), no extrahepatic shunt and non-target organ damage was found. Liver cells completely necrotic.This study shows that the method of positioning microspheres accurate, can cause local high radiant energy, which is expected to become one of the means of non-surgical treatment of liver cancer.