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心律平的药物代谢动力学呈现很大的个体差异,这与其在肝内代谢有关。本研究在10例患者中进行,男7例、女3例,年龄自42～73岁。给予口服单剂量心律平300或600mg,于第一次剂量及三天治疗的最后一次剂量之后24少时采集血样,用高效液相色谱(HPLC)法测定血浆药物浓度,估算心律平的血浆动力学。结果:第一次口服剂量后,心律平吸收缓慢,2～10小时达最高血药浓度(Cmax);平均消除半衰期(t_(1/2))为7.7±4.1(SD)小时(两端为2.9～13.7小时);药物浓度——时间(c—t)曲线下面积个体间变异很
Pharmacokinetics of cardioversion presents a large individual difference, which is related to its metabolism in the liver. The study was performed in 10 patients, 7 males and 3 females, aged from 42 to 73 years old. A single oral dose of 300 or 600 mg was given orally. Blood samples were collected 24 hours after the first dose and the last dose of the three-day treatment. The plasma drug concentrations were determined by high performance liquid chromatography (HPLC) and the plasma kinetics of the heart rhythm was estimated . RESULTS: After the first oral dose, the cardioversion was absorbed slowly and reached its maximum plasma concentration (Cmax) at 2-10 hours. The mean elimination half-life (t 1/2) was 7.7 ± 4.1 (SD) hours 2.9 to 13.7 hours); the area under the drug concentration-time (c-t) curve was highly variable