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目的：探讨中药“先心１号汤”治疗小儿单纯性先天性房、室间隔缺损的疗效。方法：将小儿单纯性先天性房、室间隔缺损患儿随机分为２组。治疗组１３３例中男６６例，女６７例；年龄６个月～１０岁（平均４．３岁）；房间隔缺损（房缺）７５例，室间隔缺损（室缺）５８例。对照组１０５例中男４９例，女５６例；年龄４个月～９岁（平均４．１岁）；房缺６１例，室缺４４例。２组患儿年龄，房、室间隔缺损分型均具可比性。治疗组用“先心１号汤”治疗；对照组不用药，观察缺损自然闭合情况。结果：治疗组患儿服药２个疗程后房缺痊愈５４例（４０．６％），好转１５例（１１．３％）；室缺痊愈４０例（３０．１％），好转１３例（９．８％），总有效率９１．７％。对照组房缺痊愈４例（３．８％），好转６例（５．７％）；室缺痊愈５例（４．８％），好转４例（３．８％），总有效率１８．１％。２组疗效比较，治疗组疗效显著优于对照组，差异显著（Ｐ＜０．０１）。结论：“先心１号汤”治疗小儿单纯性先天性房、室间隔缺损疗效肯定，安全可靠，无毒副作用，值得临床推广。确切机制尚待探讨。
Objective: To investigate the curative effect of traditional Chinese medicine “Xian Xin Yi Tang” in the treatment of simple congenital atria and ventricular septal defect in children. Methods: Children with simple congenital atrial septal defect were randomly divided into two groups. In the treatment group, there were 66 males and 67 females in 133 cases, ranging in age from 6 months to 10 years (mean, 4.3 years). There were 75 cases of atrial septal defect (atrial septal defect) and 58 cases of ventricular septal defect (atrial septal defect). The control group of 105 patients, 49 males and 56 females; aged 4 months to 9 years (mean 4.1 years); atrial septal defect in 61 cases, 44 cases of ventricular septal defect. Two groups of children age, room, ventricular septal defect type were comparable. Treatment group with “heart No. 1 soup” treatment; control group without medication to observe the natural closure of defects. Results: In the treatment group, 54 cases (40.6%) were ameliorated in 15 cases (11.3%), 40 cases (30.1%) were cured, 13 cases improved (9 .8%), the total effective rate of 91.7%. In the control group, 4 cases (3.8%) were cured and 6 cases (5.7%) were cured, 5 cases (4.8%) were cured, 4 cases (3.8%) were improved, and the total effective rate was 18 .1%. The curative effect of the two groups was significantly better than that of the control group, the difference was significant (P <0.01). Conclusion: “Xian Xin Yi Tang” treatment of children with congenital simplex room, ventricular septal defect sure, safe, reliable, non-toxic side effects, is worthy of clinical promotion. The exact mechanism remains to be explored.