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下丘脑和垂体中存在鸦片样肽,下丘脑弓状核及正中隆起中含有高浓度的β内啡肽。大量证据指出,内源性鸦片样物质通过调控下丘脑 GnRH 神经元的活动对垂体前叶机能的神经内分泌调节起抑制作用。阻断鸦片受体对于雌性性周期中垂体促性腺素的影响,其结果并不一致。本文在正常的周期性妇女进行了研究以期阐明用纳洛酮阻断鸦片受体对于同一组妇女卵泡期中期和黄体期中期中循环 FSH、LH 和泌乳素水平的影响。6例23～38岁的正常妇女,皆为规律的排卵性月经周期。平均月经周期为29.5±2.0天,平均体重为61.2±11.2kg。每一周期的卵泡期中期(7～8天)及黄体期中期(21～23天)各进行一次实验。清晨空腹向前臂静脉插入肝素化的针,30分钟以后,每15分钟取一次血,共取三次基础状态的血样。然后静脉注入10mg纳洛酮,给药后15、30、45、60、90、120及180分钟分别采血,离心将血浆贮于-20℃,用放射免疫分析法分别测定血浆 FSH、LH、催乳索以及基础水平的雌二醇和孕酮。结果
Hypothalamus and pituitary in the presence of opioid peptide, hypothalamic arcuate nucleus and the median elevation contains high concentrations of beta endorphin. A large body of evidence indicates that endogenous opioid substances inhibit the neuroendocrine regulation of the anterior pituitary gland by regulating the activity of hypothalamic GnRH neurons. The effect of blocking opioid receptors on pituitary gonadotropin in the female sexual cycle was not consistent. This study was conducted in normal cyclical women to elucidate the effects of naloxone blocking opioid receptors on circulating FSH, LH, and prolactin levels in the metaphase and mid-luteal phase of the same group of women. Six cases of normal women aged 23 to 38 years, all regular ovulatory menstrual cycle. The average menstrual cycle was 29.5 ± 2.0 days with an average body weight of 61.2 ± 11.2 kg. Each cycle of follicular metaphase (7 to 8 days) and mid luteal phase (21 to 23 days) each conducted an experiment. Fasting morning to the forearm vein heparinized needle, 30 minutes later, take a blood every 15 minutes, a total of three times take the blood of the basic state. Then intravenous injection of 10mg naloxone, 15,30,45,60,90,120 and 180 minutes after administration of blood were collected, centrifuged plasma was stored at -20 ℃, radioimmunoassay were measured plasma FSH, LH, prolactin As well as the basal levels of estradiol and progesterone. result