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目的：滋养细胞肿瘤是化疗效果最好的肿瘤之一，但化疗副反应限制临床用药剂量和强度，本文观察了思密达对化疗副反应的防治作用。方法：化疗病人朵贝尔氏液漱口后，将思密达置于喉风散瓶内，喷涂于口腔，３ ～６ 次／ 天，剂量９ｇ／ 天。常规应用止吐药。对照组只用朵贝尔氏液漱口，应用止吐药。结果：思密达组口腔溃疡、腹泻发生率均低于对照组，差异显著，Ｐ＜ ０－０５ ；口腔溃疡、腹泻、恶心呕吐持续时间思密达组均短于对照组，差异显著，Ｐ 均＜ ０－０５ 。结论：思密达能有效防治滋养细胞肿瘤化疗副反应，减少消化道副反应时间，有利于患者进食，提高化疗期间患者生存质量。
OBJECTIVE: Trophoblastic tumor is one of the best chemotherapeutic agents. However, side effects of chemotherapeutic drugs limit the dose and intensity of clinical application. We have observed the preventive and therapeutic effects of Smectite on the side effects of chemotherapy. Methods: After chemotherapy, the patient doused Bell’s mouthwash. Smectite was placed in a throat-wind bottle and sprayed on the oral cavity 3 to 6 times a day at a dose of 9 g / day. Conventional use of antiemetics. The control group only doused Bell’s mouthwash and applied antiemetics. Results: The incidence of oral ulcer and diarrhea in the Smecta group was significantly lower than that of the control group (P <0-05). The duration of oral ulcer, diarrhea and nausea and vomiting were shorter in the Smecta group than in the control group All <0-05. Conclusion: Smectite can effectively prevent and treat trophoblastic tumor chemotherapy side effects, reduce side effects of gastrointestinal tract, is conducive to patients eating, improve the quality of life of patients during chemotherapy.