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目的：探讨伽玛刀对侵袭前中颅窝底颅外恶性肿瘤的治疗效果。方法：对１０例侵袭前中颅窝底的颅外恶性肿瘤实施了伽玛刀治疗，肿瘤的病理性质包括鼻咽癌、上颌窦鳞癌、腮腺混合瘤恶变及泪腺囊性腺样癌。肿瘤体积０５～３１１ｃｍ３（平均１３６ｃｍ３），周边治疗剂量１３～２０Ｇｙ（平均１７９Ｇｙ），周边剂量曲线３０％～６０％（平均４３３％）。结果：随访３～１１个月（平均６７５月），其中６例（７个病灶）影像学检查提示有５个病灶体积缩小，１个病灶消失，另１个病灶无变化。全组临床症状无加重。结论：伽玛刀对于侵犯前中颅窝底的颅外恶性肿瘤的治疗效果满意，值得进一步研究。
Objective: To investigate the therapeutic effect of Gamma Knife on the extracranial extracranial malignant tumor before middle cranial fossa invasion. Methods: Gamma knife was applied to treat 10 cases of extracranial malignant tumors of the middle cranial fossa before invasion. The pathological features of the tumors include nasopharyngeal carcinoma, squamous cell carcinoma of the maxillary sinus, malignant transformation of the parotid gland and cystic adenoid carcinoma of the lacrimal gland. The tumor volume was 0.55-31.1 cm 3 (average 13.6 cm 3). The peripheral treatment dose was 13-20 Gy (average 17.9 Gy) and the peripheral dose curve was 30-60% (average 43.3%). Results: The follow-up ranged from 3 to 11 months (mean, 675 months). Imaging examination of 6 cases (7 lesions) showed that 5 lesions reduced in size, 1 lesions disappeared and 1 lesions did not change. The whole group had no clinical symptoms. Conclusion: Gamma Knife is satisfactory for the treatment of extracranial malignant tumors which infiltrate the anterior mid-cranial fossa, which deserves further study.