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本文采用酶联免疫吸附试验(ELISA)对78例因人工流产后所引起的不孕症、140例非人工流产不孕症以及28例正常已婚育龄妇女进行血清抗精子抗体(AsAb)检测,结果3组AsAb的阳性率分别为33.33%、15.71%、3.57%。人工流产后不孕组血清中AsAb的阳性率显著高于非人工流产不孕组和正常已婚育龄妇女(P<0.05)。提示由人工流产所引起的不孕症,在某些方面可能与免疫因素有关。文中还对人工流产后AsAb的产生和引起不孕的机理进行了讨论。子宫内膜的破损和炎症可能是AsAb产生的一个重要诱因。
In this paper, 78 cases of infertility caused by induced abortion, 140 cases of non-abortion infertility and 28 normal women of childbearing age were tested for serum anti-sperm antibody (AsAb) by enzyme-linked immunosorbent assay (ELISA) Results The positive rates of AsAb in the three groups were 33.33%, 15.71% and 3.57% respectively. The positive rate of AsAb in the abortion group was significantly higher than that in the non-abortion group and the normal married women of childbearing age (P <0.05). Prompted by the abortion caused by infertility, in some ways may be related to immune factors. The article also discussed the production of AsAb induced abortion and the mechanism of causing infertility. Endometrial damage and inflammation may be an important cause of AsAb production.