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Miconazole是用以治疗真菌感染的一种嘧唑衍生物。它已被广泛用于球状胞子虫病,且也用于少数其他真菌感染。对隐球菌脑膜炎效果不一。Miconazole过去用静脉给药或静脉与鞘内联合治疗,尚未单独鞘内用过。本文报导一例隐球菌脑膜炎用Miconazole脑室注射获得成功。 59岁男性患者,因头痛、共济失调和抽搐入院。脑脊液墨汁涂片和培养新型隐球菌阳性,隐球菌乳液凝集试验(LCAT)阳性。曾用两性霉素B治疗5月,总计静脉用药4.5克,脑室用药7.5毫克,还曾合并5—氟胞嘧啶数周(因白细胞降低而未再继续)。
Miconazole is a pyrazole derivative used to treat fungal infections. It has been used extensively for globocarcinoma and is also used for a few other fungal infections. Cryptococcal meningitis effect is different. Miconazole used to be administered intravenously or intravenously and intrathecally and has not been administered intrathecally. This article reports an example of cryptococcal meningitis with Miconazole intraventricular injection success. 59-year-old male patient admitted to hospital due to headache, ataxia and convulsions. Cerebrospinal fluid smear and culture of C. neoformans positive, cryptococcal emulsion agglutination test (LCAT) positive. Have been treated with amphotericin B in May, a total of 4.5 grams of intravenous medication, 7.5 mg of intraventricular medication, had also combined 5-fluorocytosine for several weeks (due to leukopenia did not continue).