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目的:探讨超选择动脉灌注化疗联合中药及手术治疗100例中晚期宫颈癌的临床价值。方法:选取我院收治的中晚期宫颈癌患者100例,临床分期均为Ⅱb以上,采用超选择动脉灌注化疗栓塞术联合中药及手术方法进行治疗,治疗结束后,对其中医临床症候及肿瘤实体变化、病理变化及治疗转归进行观察分析。结果:经治疗后,100例患者中,中医症候缓解总有效率为93.0%;宫颈癌实体消退总有效率为81.0%;病理切片显示:宫颈癌细胞在不同时间均出现不同程度的变性坏死,在治疗后48小时开始明显,随时间的延长坏死越明显。上述100患者中,2例患者术后出现皮下瘀斑,后经相应治疗完全消失;7例患者出现严重的下腹及腰髓疼痛,后经注射哌替啶治疗后均缓解;本组100例患者均未出现明显的肝、肾功能损害。结论:对中晚期宫颈癌患者,采用超选择动脉灌注化疗栓塞术联合中药及手术方法进行治疗,临床效果较好,不良反应较少,患者的生存质量得以提高,临床价值较高。
Objective: To investigate the clinical value of superselective arterial infusion chemotherapy combined with traditional Chinese medicine and surgical treatment of 100 cases of advanced cervical cancer. Methods: A total of 100 patients with advanced cervical cancer admitted to our hospital were enrolled in this study. The clinical stages were all over Ⅱb. The patients were treated with superselective arterial infusion chemoembolization combined with traditional Chinese medicine and operation. After the treatment, clinical symptoms and tumor entities Changes, pathological changes and treatment outcome were observed and analyzed. Results: After treatment, the total effective rate of TCM symptom relief was 93.0% in 100 patients; the total effective rate of cervical cancer subsided was 81.0%. Pathological examination showed that cervical cancer cells showed different degrees of degeneration and necrosis at different time points, 48 hours after treatment began to clear, with the extension of time the more obvious necrosis. Of the 100 patients, 2 patients had subcutaneous ecchymosis after operation and disappeared completely after the corresponding treatment. Seven patients had severe abdominal and lumbar spinal pain and were relieved after injection of pethidine. 100 patients in this group No significant liver and kidney damage occurred. Conclusion: For patients with advanced cervical cancer, super selective arterial chemoembolization combined with traditional Chinese medicine and surgical treatment, the clinical effect is better, fewer adverse reactions, the patient’s quality of life can be improved, the clinical value is higher.