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青蒿琥酯(artesunate)是青蒿素(artemisinin)的一种衍生物,具有抗疟、抗血吸虫、抗心律失常、免疫调节等功能。青蒿素类化合物对多种实体肿瘤细胞如肝癌、胃癌、乳腺癌、结肠癌、宫颈癌等多种肿瘤均具有抗癌活性,而且对正常组织细胞的毒性很低。近来,越来越多研究显示,青蒿琥酯能够抑制多发性骨髓瘤(multiple myeloma,MM)细胞的生长。并通过抑制骨髓血管新生,逆转骨髓瘤细胞多药耐药等多种机制,抑制多发性骨髓瘤的发生、发展。
Artesunate is a derivative of artemisinin that has anti-malarial, anti-schistosome, anti-arrhythmic, immunomodulatory and other functions. Artemisinin compounds have anticancer activity against many kinds of solid tumor cells such as liver cancer, stomach cancer, breast cancer, colon cancer and cervical cancer, and have low toxicity to normal tissue cells. Recently, more and more studies have shown that artesunate can inhibit the growth of multiple myeloma (MM) cells. And through the inhibition of bone marrow angiogenesis, reversal of myeloma multidrug resistance and other mechanisms, inhibition of the occurrence and development of multiple myeloma.