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作者对22例经临床、实验室和/或病理检查诊新的慢性肝病患者,包括慢性活动性肝炎(CAH)6例、肝硬化(LC)11例和肝细胞癌(HCC)5例,应用高能液体色层分析法,测定血浆哌可酸(pipecolic acid)水平。另同时测定胆石症、梗阻性黄疸和慢性胰腺炎各1例及12名正常人的血浆哌可酸水平,作为对照.每例患者并同时测定胆红素、天门冬氨酸氨基转移酶(AST)、碱性碑酸酶、胆碱酯酶、γ-谷氨酰转肽酶(γ-GT)、胆固醇、胆酸、白蛋白、凝血酶原时间、血尿素氮、血清肌酐和靛氰绿,并估价与血浆哌可酸的关系,结果如下。
The authors of 22 patients with chronic liver disease diagnosed by clinical, laboratory and / or pathological examination included 6 cases of chronic active hepatitis (CAH), 11 cases of liver cirrhosis (LC) and 5 cases of hepatocellular carcinoma (HCC). High-energy liquid chromatography, determination of plasma pipecolic acid levels. In addition, the level of plasma picric acid was also determined in 1 case of cholelithiasis, 1 case of obstructive jaundice and chronic pancreatitis, and 12 cases of normal persons as control.All patients were also tested for bilirubin, aspartate aminotransferase ), Alkaline peptidase, cholinesterase, gamma-GT, cholesterol, cholic acid, albumin, prothrombin time, blood urea nitrogen, serum creatinine and indocyanine green , And evaluate the relationship with plasma pipecolic acid, the results are as follows.